par Swillens, Stéphane ;Dumont, Jacques Emile
Référence Molecular and cellular endocrinology, 20, 3, page (233-242)
Publication Publié, 1980
Référence Molecular and cellular endocrinology, 20, 3, page (233-242)
Publication Publié, 1980
Article révisé par les pairs
Résumé : | Pharmacological drugs activate cellular functions by binding to specific receptors. Experimental observations have shown that, in many systems, the drug effect is half-maximally elicited at drug concentrations far lower than those required for saturating half the receptors. In the case of the β-adrenergic system, such a discrepancy can be correlated with the efficacy of agonists in activating the adenylate cyclase. It is shown in this paper that, within the framework of the model describing the receptor-adenylate cyclase interaction, the experimentally observed discrepancy between binding and activation is a direct consequence of the structure of the system and is, in fact, an index of the drug efficacy. |