par Waelbroeck, Magali 
;De Neef, Philippe ;Robberecht, Patrick ;Christophe, Jean
Référence Life sciences, 35, 10, page (1069-1076)
Publication Publié, 1984
;De Neef, Philippe ;Robberecht, Patrick ;Christophe, Jean Référence Life sciences, 35, 10, page (1069-1076)
Publication Publié, 1984
Article révisé par les pairs
| Résumé : | Quinidine inhibited binding of the labelled agonist [3H]oxotremorine M ([3HOxo-M) and the labelled antagonist [3H]N-methylscopolamine ([3H]NMS) to rat heart muscarinic receptors. Kinetic studies demonstrated that quinidine decreased the association rates (I50: 4 and 7.5 μM) and dissociation rates (I50: 100 and 68 μM) of [3H]Oxo-M and [3H]NMS, with different potencies. These cooperative effects explained the low Hill coefficients and apparent selectivity of quinidine competition curves. |
