par Abramowicz, Daniel 
;Pradier, Olivier ;Marchant, Arnaud ;Florquin, Sandrine ;De Pauw, Luc ;Vereerstraeten, Pierre ;Kinnaert, Paul ;Vanherweghem, Jean-Louis ;Goldman, Michel
Référence Lancet, 339, 8796, page (777-778)
Publication Publié, 1992
;Pradier, Olivier ;Marchant, Arnaud ;Florquin, Sandrine ;De Pauw, Luc ;Vereerstraeten, Pierre ;Kinnaert, Paul ;Vanherweghem, Jean-Louis ;Goldman, Michel Référence Lancet, 339, 8796, page (777-778)
Publication Publié, 1992
Article révisé par les pairs
| Résumé : | Among 93 consecutive kidney-transplant patients who received prophylactic OKT3 10 mg/day for 2 weeks, 9 had intragraft thromboses within 2 weeks of transplantation. The thromboses were in graft artery in 1 patient and veins in 3. The other 5 had thromboses in glomerular capillaries and thrombotic microangiopathy similar to that of haemolytic-uraemic syndrome. All attempted treatments failed, and the 9 grafts had to be removed. The finding that plasma concentrations of prothrombin fragment 1 and 2 were higher 4 h after the first OKT3 dose in OKT3 recipients than in transplant patients who received other prophylaxis (mean 5.88 [SEM 0.76] vs 2.25 [0.59] nmol/l, p < 0.01) confirms that OKT3 has procoagulant effects in vivo. |
