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Specific interaction between follitropin and GM1 ganglioside incorporated into lipid membranes.

par Deleers, Michel ;Chatelain, Pierre ;Poss, A;Ruysschaert, Jean Marie
Référence Biochemical and biophysical research communications, 89, 4, page (1102-1106)
Publication Publié, 1979-08

Article révisé par les pairs

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Résumé :

A specific interaction was demonstrated between a monosialo-ganglioside (galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide) incorporated in glycerol monoleate planar bilayer membranes and follitropin. Conductance of glycerol monoleate planar bilayer membranes containing gangliosides were measured before and after addition of follitropin in the aqueous phase. A 5 fold increase of membrane conductance was observed in presence of a specific monosialo-ganglioside. No significant effect was obtained with di- and trisialogangliosides. Membrane conductance changes were suppressed by the presence of an equimolar mixture of the saccharide residues (galactose, N-acetylgalactosamine and N-acetylneuraminic acid) present in the hydrophilic moeity of the ganglioside. The results favour the hypothesis that gangliosides may contribute to the formation of functional glycoproteins receptors.