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Adriamycin inhibits the formation of non-bilayer lipid structures in cardiolipin-containing model membranes.

par Goormaghtigh, Erik ;Vandenbranden, Michel ;Ruysschaert, Jean Marie ;de Kruijff, B
Référence Biochimica et biophysica acta, 685, 2, page (137-143)
Publication Publié, 1982-02

Article révisé par les pairs

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Résumé :

The effect of adriamycin on cardiolipin-containing model membrane systems have been studied by 31P-NMR, freeze-fracture electron microscopy and binding experiments. Adriamycin effectively inhibits the formation of non-bilayer lipid structures induced by Ca2+ and cytochrome c in cardiolipin-containing liposomes. This drug also strongly inhibits the uptake of Ca2+ by cardiolipin into an organic phase. These results are discussed in relation to the cardiotoxic effect of adriamycin and the possible importance of non-bilayer lipid structures for the functioning of the mitochondrion.