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Sequence of ionophore conformational changes induced by a simulated membrane/water interface.

par Brasseur, Robert ;Deleers, Michel ;Ruysschaert, Jean Marie
Référence Bioscience reports, 4, 8, page (651-658)
Publication Publié, 1984-08

Article révisé par les pairs

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Résumé :

We demonstrate how the progressive passage through an interface simulated by a linear increase in dielectric constant may mediate a reversible transconformation of Na+/X537A (lasalocid A) from a cyclic to an extended structure. During the passage through the interface, the complex adopts progressively a more extended conformation favorable to the Na+ complexation or decomplexation at the interface.