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Properties of amiodarone monolayer spread at the air-water interface.

par Ferreira, José ;Brasseur, Robert ;Chatelain, Pierre ;Ruysschaert, Jean Marie
Référence Journal of Pharmacy and Pharmacology, 38, 8, page (561-566)
Publication Publié, 1986-08

Article révisé par les pairs

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Résumé :

Surface pressure measurements demonstrate that, over a wide range of pH, amiodarone forms a stable monolayer at the air-water interface. The area found to be occupied by an amiodarone molecule was compared with a theoretical prediction based on a conformational analysis, making it possible to assemble amphiphilic molecules. The intrinsic ionization constant of amiodarone in an aqueous environment pKi = 8.7 +/- 0.5 was evaluated from surface potential measurements.