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Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate II. Ionophoretic and conformational aspects

par Malaisse, Willy ;Bakkali Nadi, Abdellatif ;Malaisse Lagae, Francine ;Sato, Fumiyasatu;Lins, Laurence;Brasseur, Robert
Référence General pharmacology, 26, 6, page (1319-1325)
Publication Publié, 1995

Article révisé par les pairs

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Résumé :

1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells.