par Malaisse, Willy 
;Zhang, Ying ;Louchami, Karim ;Sener, Abdullah ;Portois, Laurence ;Carpentier, Yvon
Référence Neuroscience letters, 409, 1, page (75-79)
Publication Publié, 2006-11
;Zhang, Ying ;Louchami, Karim ;Sener, Abdullah ;Portois, Laurence ;Carpentier, Yvon Référence Neuroscience letters, 409, 1, page (75-79)
Publication Publié, 2006-11
Article révisé par les pairs
| Résumé : | The liver phospholipid and triglyceride content and/or fatty acid pattern differ(s) not solely in normal versus diabetic rats, but also in distinct rat models of diabetes mellitus. The present study reveals that a comparable situation prevails in the brain. Fed and overnight fasted female normal rats (N) and Goto-Kakizaki rats (GK), as well as fed rats rendered diabetic by a prior injection 3 days before sacrifice of streptozotocin (STZ) were examined. The brain phospholipid content, expressed as milligrams of fatty acids per gram wet weight, was comparable in all groups of rats, with an overall mean value of 31.2 ± 0.8 (n = 22). The GK rats differed from N and STZ rats by lower C18:0/C18:1ω9 and C18:2ω6/C18:3ω6 ratios and a lower C20:5ω3 content of brain phospholipids. The total amount of fatty acids in triglycerides was 7-8 times higher in GK than N and STZ rats. The GK rats differed from N and STZ rats by lower C16:0/C16:1ω7, C18:0/C18:1ω9 and (C16:0 + C16:1ω7)/(C18:0 + C18:1ω9) ratios in triglycerides. These findings extend to the brain, the knowledge of alterations in phospholipid and triglyceride content and/or fatty acid pattern in GK rats, as compared to N or STZ rats. The former rats indeed displayed: (i) an apparently increased activity of Δ9- and Δ6-desaturases, as suggested by the phospholipid measurements, and a decreased C20:5ω3 content in such phospholipids; (ii) a dramatic increase in brain triglyceride content; and (iii) an increased activity of Δ9-desaturase, as well as elongase, as judged from the triglyceride data. © 2006 Elsevier Ireland Ltd. All rights reserved. |
