par Carpentier, Yvon 
;Portois, Laurence ;Louchami, Karim ;Zhang, Ying ;Sener, Abdullah ;Malaisse, Willy
Référence Cell biochemistry and function, 26, 1, page (33-38)
Publication Publié, 2008-01
;Portois, Laurence ;Louchami, Karim ;Zhang, Ying ;Sener, Abdullah ;Malaisse, Willy Référence Cell biochemistry and function, 26, 1, page (33-38)
Publication Publié, 2008-01
Article révisé par les pairs
| Résumé : | Rats depleted in long-chain polyunsaturated ω3 fatty acids (ω3-depleted rats) display several features of the metabolic syndrome including hypertension and cardiac hypertrophy. This coincides with alteration of the cardiac muscle phospholipid and triacylglycerol fatty acid content and/or pattern. In the present study, the latter variables were measured in the cardiac endothelium of normal and ω3-depleted rats. Samples derived from four rats each were obtained from 16 female normal fed rats and three groups of 36-40 female fed ω3-depleted rats each aged 8-9, 15-16 and 22-23 weeks. At comparable mean age, the ratio between the square root of the total fatty acid content of phospholipids and cubic root of the total fatty acid content of triacylglycerols was lower in ω3-depleted rats than in control animals. The total fatty acid content of triacylglycerols was inversely related to their relative content in C20:4ω6. Other differences between ω3-depleted rats and control animals consisted in a lower content of long-chain polyunsaturated ω3 fatty acids in both phospholipids and triacylglycerols, higher content of long-chain polyunsaturated ω6 fatty acids in phospholipids, higher activity of Δ9-desaturase (C16:0/C16:1ω7 and C18:0/C18:1ω9 ratios) and elongase [(C16:0 + C16:1ω7)/(C18:0 + C18:1ω9) and C20:4ω6/C22:4ω6 ratios], but impaired generation of C22:6ω3 from C22:5ω3 in the former rats. These findings support the view that cardiovascular perturbations previously documented in the ω3-depleted rats may involve impaired heart endothelial function. Copyright © 2007 John Wiley & Sons, Ltd. |
