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Characterization of the p53 response to oncogene-induced senescence.

par Ruiz, Lidia;Traskine, Magali ;Ferrer, Irene;Castro, Estrella;Leal, Juan F M;Kaufman, Marcelle ;Carnero, Amancio
Référence PloS one, 3, 9, page (3230)
Publication Publié, 2008

Article révisé par les pairs

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Résumé :

P53 activation can trigger various outcomes, among them reversible growth arrest or cellular senescence. It is a live debate whether these outcomes are influenced by quantitative or qualitative mechanisms. Furthermore, the relative contribution of p53 to Ras-induced senescence is also matter of controversy.