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Cancer phenotype as the outcome of an evolutionary game between normal and malignant cells.

par Dingli, D.;Chalub, F A C C;Santos, F C;Van Segbroeck, Sven ;Pacheco, Jorge J.M.
Référence British Journal of Cancer, 101, 7, page (1130-1136)
Publication Publié, 2009-10

Article révisé par les pairs

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Résumé :

There is variability in the cancer phenotype across individuals: two patients with the same tumour may experience different disease life histories, resulting from genetic variation within the tumour and from the interaction between tumour and host. Until now, phenotypic variability has precluded a clear-cut identification of the fundamental characteristics of a given tumour type.