par Grosflis, K;Metioui, Mourad ;Lenoble, S;Dehaye, Jean-Paul
Référence General pharmacology, 27, 6, page (1041-1046)
Publication Publié, 1996-09
Article révisé par les pairs
Résumé : 1. Caffeine did not affect by itself the amylase release, nor intracellular calcium concentration in rat pancreatic acini. 2. Concentration of caffeine higher than 1 mM inhibited the amylase released in response to the muscarinic agonist carbamylcholine. This inhibition was also seen on the intracellular calcium elevation: 20 mM caffeine inhibited by 80% the calcium elevation in response to 100 microM carbachol. 3. Caffeine also prevented the specific binding of [3H]-N-methylscopolamine ([3H]-NMS) on rat pancreatic muscarinic receptors. 4. We conclude that caffeine behaves as a muscarinic antagonist.

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