Article révisé par les pairs
Titre:
  • New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.
Auteur:Florence, Xavier; Sebille, Sophie; de Tullio, Pascal; Lebrun, Philippe; Pirotte, Bernard
Informations sur la publication:Bioorganic & medicinal chemistry, 17, 22, page (7723-7731)
Statut de publication:Publié, 2009-11
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Benzopyran derivatives
Cromakalim analogues
KATP channels
Potassium channel openers
MeSH keywords:Adenosine Triphosphate -- metabolism
Animals
Benzopyrans -- chemical synthesis
Benzopyrans -- chemistry
Benzopyrans -- pharmacology
Cromakalim -- chemistry
Cromakalim -- pharmacology
Diazoxide -- chemistry
Diazoxide -- pharmacology
Islets of Langerhans -- drug effects
Islets of Langerhans -- metabolism
Muscle, Smooth, Vascular -- drug effects
Muscle, Smooth, Vascular -- metabolism
Pinacidil -- chemistry
Pinacidil -- pharmacology
Potassium Channels -- agonists
Potassium Channels -- metabolism
Rats
Rats, Wistar
Stereoisomerism
Structure-Activity Relationship
Vasodilator Agents -- chemical synthesis
Vasodilator Agents -- chemistry
Vasodilator Agents -- pharmacology
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0968-0896
info:doi/10.1016/j.bmc.2009.09.041
info:pii/S0968-0896(09)00893-1
info:scp/71749086139
info:pmid/19822435