K+ channel openers and insulin release.

Lebrun, Philippe; Antoine, Marie-Hélène; Herchuelz, André

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K+ channel openers and insulin release.

par Lebrun, Philippe

;Antoine, Marie-Hélène

;Herchuelz, André

Référence Life sciences, 51, 11, page (795-806)
Publication Publié, 1992

Article révisé par les pairs

Résumé :

Recent in vivo and in vitro experiments suggested that the smooth muscle relaxation mediated by diverse pharmacologic agents resulted from K+ channel opening. Pinacidil, cromakalim, nicorandil, RP 49356, minoxidil sulfate and diazoxide belong to this new group of smooth muscle relaxants: the "K+ channel openers". Because modifications in the K+ permeability are known to represent a critical event in the insulin-releasing process, numerous studies have been performed in order to examine the putative effects of K+ channel openers on B-cell function. The aim of the present review is to summarize these experimental data which are sometimes divergent.

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