par Malaisse, Willy 
;Sener, Abdullah ;Levy, J.;Herchuelz, André
Référence Acta diabetologica latina, 13, 5-6, page (202-215)
Publication Publié, 1976
;Sener, Abdullah ;Levy, J.;Herchuelz, André Référence Acta diabetologica latina, 13, 5-6, page (202-215)
Publication Publié, 1976
Article révisé par les pairs
| Résumé : | When isolated islets of Langerhans are suddenly exposed to glucose, the entry of the hexose into islet cells first occurs at a high rate resulting in rapid equilibration of free glucose across the cell membrane; thereafter, the rate of net glucose uptake depends on its metabolism. More than 95% of the glucose taken up by the islets is converted to triosephosphate. The fractional contribution of the sorbitol and pentose-phosphate pathways to such a process does not exceed 10%. The output of lactate from the islets accounts for approximately half of the glycolytic flux. At increasing glucose concentrations up to 4.3 mM, the rate of glycolysis increases towards a first asymptotic value; at higher glucose levels (up to 27.8 mM), a sigmoidal pattern is seen tending towards a second saturation value. The total ATP content of the islets does not correlate with their insulin-secretory activity. It is suggested that, in the process of glucose-induced insulin release, glycolysis may regulate physiological processes possibly located in the micro-environment of the cell boundary. |
