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Increase in CO3H- influx and cellular pH in glucose-stimulated pancreatic islets.

par Deleers, M;Lebrun, Philippe ;Malaisse, Willy
Référence FEBS letters, 154, 1, page (97-100)
Publication Publié, 1983-04

Article révisé par les pairs

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Résumé :

When rat islets are preincubated with fluorescein diacetate and examined in a spectrofluorometer, the intracellular pH rapidly increases by 0.21 pH units in response to a rise from 1.7-16.8 mM glucose. This coincides with a marked increase in 14CO3H- net uptake by the islets, suggesting that the glucose-induced increase in H+ generation rate is compensated for by stimulation of CO3H-/Cl- exchange.