• Citer

4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships.

par Pirotte, B;Podona, T;Diouf, O;de Tullio, Pascal;Lebrun, Philippe ;Dupont, L;Somers, Fabian;Delarge, Jacques;Morain, P;Lestage, P;Lepagnol, J;Spedding, Michael
Référence Journal of medicinal chemistry, 41, 16, page (2946-2959)
Publication Publié, 1998-07

Article révisé par les pairs

• Détails
• Contenu

Titre:	4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships.
Auteur:	Pirotte, B; Podona, T; Diouf, O; de Tullio, Pascal; Lebrun, Philippe; Dupont, L; Somers, Fabian; Delarge, Jacques; Morain, P; Lestage, P; Lepagnol, J; Spedding, Michael
Informations sur la publication:	Journal of medicinal chemistry, 41, 16, page (2946-2959)
Statut de publication:	Publié, 1998-07
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenosine Triphosphate -- metabolism
	Allosteric Regulation
	Animals
	Benzothiadiazines -- chemistry
	Benzothiadiazines -- pharmacology
	Cerebral Cortex -- metabolism
	Cyclic S-Oxides -- chemical synthesis
	Cyclic S-Oxides -- chemistry
	Cyclic S-Oxides -- pharmacology
	Diazoxide -- chemistry
	Diazoxide -- pharmacology
	Drug Design
	Excitatory Postsynaptic Potentials -- drug effects
	Hippocampus -- drug effects
	Hippocampus -- metabolism
	Hippocampus -- physiology
	Insulin -- secretion
	Insulin Antagonists -- chemical synthesis
	Insulin Antagonists -- chemistry
	Insulin Antagonists -- pharmacology
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- metabolism
	Islets of Langerhans -- secretion
	Male
	Mice
	Mice, Inbred DBA
	Oocytes -- drug effects
	Oocytes -- metabolism
	Potassium Channels -- drug effects
	RNA, Messenger -- biosynthesis
	Rats
	Rats, Wistar
	Receptors, AMPA -- biosynthesis
	Receptors, AMPA -- drug effects
	Receptors, AMPA -- genetics
	Solubility
	Stereoisomerism
	Structure-Activity Relationship
	Thiadiazines -- chemical synthesis
	Thiadiazines -- chemistry
	Thiadiazines -- pharmacology
	Xenopus laevis
Note générale:	In Vitro
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm970694v
	info:pii/jm970694v
	info:scp/15644381026
	info:pmid/9685234