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Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.

par de Tullio, Pascal;Becker, Bénédicte ;Boverie, Stéphane;Dabrowski, Michael;Wahl, Philip;Antoine, Marie-Hélène ;Somers, Fabian;Sebille, Sophie;Ouedraogo, Raogo;Hansen, John Bondo;Lebrun, Philippe ;Pirotte, Bernard
Référence Journal of medicinal chemistry, 46, 15, page (3342-3353)
Publication Publié, 2003-07

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Titre:	Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
Auteur:	de Tullio, Pascal; Becker, Bénédicte; Boverie, Stéphane; Dabrowski, Michael; Wahl, Philip; Antoine, Marie-Hélène; Somers, Fabian; Sebille, Sophie; Ouedraogo, Raogo; Hansen, John Bondo; Lebrun, Philippe; Pirotte, Bernard
Informations sur la publication:	Journal of medicinal chemistry, 46, 15, page (3342-3353)
Statut de publication:	Publié, 2003-07
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenosine Triphosphate -- metabolism
	Animals
	Aorta -- drug effects
	Aorta -- physiology
	Benzothiadiazines
	Diazoxide -- analogs & derivatives
	Diazoxide -- chemical synthesis
	Diazoxide -- chemistry
	Diazoxide -- pharmacology
	Female
	Glucose -- pharmacology
	Insulin -- secretion
	Ion Channel Gating
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- metabolism
	Islets of Langerhans -- secretion
	Isomerism
	Molecular Conformation
	Muscle Relaxation -- drug effects
	Muscle, Smooth, Vascular -- drug effects
	Muscle, Smooth, Vascular -- physiology
	Oocytes -- drug effects
	Oocytes -- physiology
	Organ Specificity
	Patch-Clamp Techniques
	Potassium Channels -- drug effects
	Rats
	Rats, Wistar
	Structure-Activity Relationship
	Xenopus laevis
Note générale:	In Vitro
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm021117w
	info:scp/0037479902
	info:pmid/12852765