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Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels.

par Schou, Søren C;Hansen, Holger C;Tagmose, Tina M;Boonen, Harrie C M;Worsaae, Anne;Drabowski, Michael;Wahl, Philip;Arkhammar, Per O G;Bodvarsdottir, Thora;Antoine, Marie-Hélène ;Lebrun, Philippe ;Hansen, John Bondo
Référence Bioorganic & medicinal chemistry, 13, 1, page (141-155)
Publication Publié, 2005-01

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Titre:	Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels.
Auteur:	Schou, Søren C; Hansen, Holger C; Tagmose, Tina M; Boonen, Harrie C M; Worsaae, Anne; Drabowski, Michael; Wahl, Philip; Arkhammar, Per O G; Bodvarsdottir, Thora; Antoine, Marie-Hélène; Lebrun, Philippe; Hansen, John Bondo
Informations sur la publication:	Bioorganic & medicinal chemistry, 13, 1, page (141-155)
Statut de publication:	Publié, 2005-01
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenosine Triphosphate -- pharmacology
	Amides -- chemical synthesis
	Amides -- pharmacology
	Animals
	Cell Line
	Drug Evaluation, Preclinical
	Humans
	Magnetic Resonance Spectroscopy
	Mass Spectrometry
	Membrane Potentials -- drug effects
	Nitriles -- chemical synthesis
	Nitriles -- pharmacology
	Patch-Clamp Techniques
	Potassium Channels -- agonists
	Spectrophotometry, Infrared
	Thiazines -- chemical synthesis
	Thiazines -- pharmacology
Note générale:	Journal Article
Langue:	Anglais
Identificateurs:	urn:issn:0968-0896
	info:doi/10.1016/j.bmc.2004.09.051
	info:pii/S0968-0896(04)00768-0
	info:scp/9644255738
	info:pmid/15582459