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Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.

par Boverie, Stéphane;Antoine, Marie-Hélène ;Somers, Fabian;Becker, Bénédicte ;Sebille, Sophie;Ouedraogo, Raogo;Counerotte, Stéphane;Pirotte, Bernard;Lebrun, Philippe ;de Tullio, Pascal
Référence Journal of medicinal chemistry, 48, 10, page (3492-3503)
Publication Publié, 2005-05

Article révisé par les pairs

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Titre:	Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.
Auteur:	Boverie, Stéphane; Antoine, Marie-Hélène; Somers, Fabian; Becker, Bénédicte; Sebille, Sophie; Ouedraogo, Raogo; Counerotte, Stéphane; Pirotte, Bernard; Lebrun, Philippe; de Tullio, Pascal
Informations sur la publication:	Journal of medicinal chemistry, 48, 10, page (3492-3503)
Statut de publication:	Publié, 2005-05
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenosine Triphosphate -- physiology
	Animals
	Aorta -- drug effects
	Aorta -- physiology
	Benzothiadiazines -- chemical synthesis
	Benzothiadiazines -- chemistry
	Benzothiadiazines -- pharmacology
	Insulin -- secretion
	Ion Channel Gating
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- secretion
	Muscle Contraction -- drug effects
	Muscle, Smooth, Vascular -- drug effects
	Muscle, Smooth, Vascular -- physiology
	Potassium Channels -- agonists
	Rats
	Rats, Wistar
	Structure-Activity Relationship
	Vasodilator Agents -- chemical synthesis
	Vasodilator Agents -- chemistry
	Vasodilator Agents -- pharmacology
Note générale:	In Vitro
	Journal Article
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm0311339
	info:scp/20844445619
	info:pmid/15887958