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Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

par Khelili, Smail;Florence, Xavier ;Bouhadja, Mourad;Abdelaziz, Samia;Mechouch, Nadia;Mohamed, Yekhlef;de Tullio, Pascal;Lebrun, Philippe ;Pirotte, Bernard
Référence Bioorganic & medicinal chemistry, 16, 11, page (6124-6130)
Publication Publié, 2008-06

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Titre:	Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
Auteur:	Khelili, Smail; Florence, Xavier; Bouhadja, Mourad; Abdelaziz, Samia; Mechouch, Nadia; Mohamed, Yekhlef; de Tullio, Pascal; Lebrun, Philippe; Pirotte, Bernard
Informations sur la publication:	Bioorganic & medicinal chemistry, 16, 11, page (6124-6130)
Statut de publication:	Publié, 2008-06
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Inhibition of insulin secretion
	Potassium channel opener
	Ring-opened cromakalim analogues
	Vasorelaxant effect
MeSH keywords:	Animals
	Aorta -- drug effects
	Aorta -- metabolism
	Benzopyrans -- chemical synthesis
	Benzopyrans -- chemistry
	Benzopyrans -- pharmacology
	Chromans -- chemical synthesis
	Chromans -- chemistry
	Chromans -- pharmacology
	Cromakalim -- analogs & derivatives
	Cromakalim -- pharmacology
	Insulin -- secretion
	Insulin Antagonists -- chemical synthesis
	Insulin Antagonists -- pharmacology
	Insulin-Secreting Cells -- drug effects
	Insulin-Secreting Cells -- metabolism
	Insulin-Secreting Cells -- secretion
	Muscle Relaxation -- drug effects
	Potassium Channels -- metabolism
	Rats
	Rats, Wistar
Note générale:	In Vitro
	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0968-0896
	info:doi/10.1016/j.bmc.2008.04.043
	info:pii/S0968-0896(08)00375-1
	info:scp/44449092065
	info:pmid/18479927