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Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.

par Pirotte, Bernard;de Tullio, Pascal;Nguyen, Quynh Anh ;Somers, Fabian;Fraikin, Pierre;Florence, Xavier ;Wahl, Philip;Hansen, John Bondo;Lebrun, Philippe
Référence Journal of medicinal chemistry, 53, 1, page (147-154)
Publication Publié, 2010-01

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Titre:	Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
Auteur:	Pirotte, Bernard; de Tullio, Pascal; Nguyen, Quynh Anh; Somers, Fabian; Fraikin, Pierre; Florence, Xavier; Wahl, Philip; Hansen, John Bondo; Lebrun, Philippe
Informations sur la publication:	Journal of medicinal chemistry, 53, 1, page (147-154)
Statut de publication:	Publié, 2010-01
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenosine Triphosphate -- metabolism
	Animals
	Benzothiadiazines -- chemical synthesis
	Benzothiadiazines -- chemistry
	Benzothiadiazines -- pharmacology
	Cell Line
	Chlorine -- chemistry
	Cyclic S-Oxides -- chemical synthesis
	Cyclic S-Oxides -- chemistry
	Cyclic S-Oxides -- pharmacology
	Diazoxide -- analogs & derivatives
	Diazoxide -- chemistry
	Diazoxide -- pharmacology
	Drug Evaluation, Preclinical
	Glucose -- pharmacology
	Humans
	Insulin -- secretion
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- secretion
	Molecular Structure
	Muscle, Smooth, Vascular -- drug effects
	Muscle, Smooth, Vascular -- metabolism
	Potassium Channels -- drug effects
	Potassium Channels -- metabolism
	Rats
	Stereoisomerism
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm9010093
	info:pmid/19919106