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Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.

par Gillotin, Florian;Chiap, Patrice;Frédérich, Michel;Van Heugen, Jean-Claude;Francotte, Pierre;Lebrun, Philippe ;Pirotte, Bernard;de Tullio, Pascal
Référence Drug metabolism and disposition, 38, 2, page (232-240)
Publication Publié, 2010-02

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Titre:	Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.
Auteur:	Gillotin, Florian; Chiap, Patrice; Frédérich, Michel; Van Heugen, Jean-Claude; Francotte, Pierre; Lebrun, Philippe; Pirotte, Bernard; de Tullio, Pascal
Informations sur la publication:	Drug metabolism and disposition, 38, 2, page (232-240)
Statut de publication:	Publié, 2010-02
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	ATP-Binding Cassette Transporters -- metabolism
	Animals
	Benzothiadiazines -- metabolism
	Chromatography, High Pressure Liquid -- methods
	Cyclic S-Oxides -- metabolism
	Diazoxide -- analogs & derivatives
	Diazoxide -- metabolism
	Humans
	Ion Channel Gating -- drug effects
	Isomerism
	KATP Channels -- metabolism
	Magnetic Resonance Spectroscopy -- methods
	Male
	Membrane Transport Modulators -- metabolism
	Metabolic Detoxication, Phase I
	Microsomes, Liver -- metabolism
	Phenobarbital -- pharmacology
	Potassium Channels, Inwardly Rectifying -- metabolism
	Protein Isoforms -- antagonists & inhibitors
	Protein Isoforms -- metabolism
	Rats
	Rats, Sprague-Dawley
	Receptors, Drug -- metabolism
	Solid Phase Extraction -- methods
	Tandem Mass Spectrometry -- methods
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0090-9556
	info:doi/10.1124/dmd.109.028928
	info:pii/dmd.109.028928
	info:scp/76149084797
	info:pmid/19875500