par Martiat, Philippe ;Mecucci, C;Nizet, Y;Stul, Michel;Philippe, M;Cassiman, J.-J.;Michaux, Jean Louis;Van den Berghe, Herman;Sokal, G
Référence Leukemia, 4, 11, page (751-754)
Publication Publié, 1990-11
Référence Leukemia, 4, 11, page (751-754)
Publication Publié, 1990-11
Article révisé par les pairs
Résumé : | Philadelphia positive multiple myeloma is a very rare event and, so far, no molecular data about the involvement of the BCR and C-ABL genes are available. We report here the case of a 64-year-old woman presenting with a typical multiple myeloma and a complex Philadelphia (Ph) chromosome that we investigated at a molecular level using conventional DNA techniques and the polymerase chain reaction (PCR). No rearrangement was observed within the major breakpoint cluster region (M-BCR) although she was found to have a P190 BCR/ABL hybrid transcript using PCR. As far as we know, this is the first description of a P190-type mRNA in a patient with a chronic lymphoid disorder. Since P190 is almost always associated in man with acute forms of hematological malignancies, this suggests that other factors may play a role in determining the phenotype of the disease. |