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Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

par Srinivasan, Supriya;Lubrano-Berthelier, Cecile;Govaerts, Cédric ;Picard, Franck;Santiago, Pamela;Conklin, Bruce R;Vaisse, Christian
Référence The Journal of clinical investigation, 114, 8, page (1158-1164)
Publication Publié, 2004-10

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Titre:	Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.
Auteur:	Srinivasan, Supriya; Lubrano-Berthelier, Cecile; Govaerts, Cédric; Picard, Franck; Santiago, Pamela; Conklin, Bruce R; Vaisse, Christian
Informations sur la publication:	The Journal of clinical investigation, 114, 8, page (1158-1164)
Statut de publication:	Publié, 2004-10
Sujet CREF:	Sciences bio-médicales et agricoles
	Biochimie
	Biologie
	Biologie cellulaire
	Biologie moléculaire
	Biophysique
	Sciences biomédicales
	Sciences de la matière vivante
MeSH keywords:	Agouti-Related Protein
	Amino Acid Sequence
	Animals
	Cell Line
	Cyclic AMP -- metabolism
	Drug Design
	Eating
	Energy Metabolism
	Homeostasis
	Humans
	Intercellular Signaling Peptides and Proteins
	Ligands
	Mice
	Molecular Sequence Data
	Obesity -- genetics
	Obesity -- metabolism
	Point Mutation
	Protein Structure, Secondary
	Proteins -- metabolism
	Receptor, Melanocortin, Type 4 -- chemistry
	Receptor, Melanocortin, Type 4 -- genetics
	Receptor, Melanocortin, Type 4 -- metabolism
	Second Messenger Systems -- physiology
	Transcriptional Activation
	alpha-MSH -- metabolism
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	Research Support, U.S. Gov't, P.H.S.
Langue:	Anglais
Identificateurs:	urn:issn:0021-9738
	info:doi/10.1172/JCI21927
	info:pmid/15489963
	PMC522250