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Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.

par Rai, Myriam ;Soragni, Elisabetta;Chou, C James;Barnes, Glenn;Jones, Steve;Rusche, James R;Gottesfeld, Joel M;Pandolfo, Massimo
Référence PloS one, 5, 1, page (e8825)
Publication Publié, 2010

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Titre:	Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.
Auteur:	Rai, Myriam; Soragni, Elisabetta; Chou, C James; Barnes, Glenn; Jones, Steve; Rusche, James R; Gottesfeld, Joel M; Pandolfo, Massimo
Informations sur la publication:	PloS one, 5, 1, page (e8825)
Statut de publication:	Publié, 2010
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Base Sequence
	DNA Primers
	Disease Models, Animal
	Friedreich Ataxia -- genetics
	Histone Deacetylase Inhibitors -- pharmacology
	Humans
	Iron-Binding Proteins -- genetics
	Mice
	Models, Animal
	Pimelic Acids -- pharmacology
	Polymerase Chain Reaction
	Up-Regulation -- drug effects
Note générale:	Journal Article
	Research Support, N.I.H., Extramural
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:1932-6203
	info:doi/10.1371/journal.pone.0008825
	info:scp/77749249631
	info:pmid/20098685
	PMC2809102