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Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids.

par Mollereau, Catherine;Moisand, C;Butour, J L;Parmentier, Marc ;Meunier, J C
Référence FEBS letters, 395, 1, page (17-21)
Publication Publié, 1996-10

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Titre:	Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids.
Auteur:	Mollereau, Catherine; Moisand, C; Butour, J L; Parmentier, Marc; Meunier, J C
Informations sur la publication:	FEBS letters, 395, 1, page (17-21)
Statut de publication:	Publié, 1996-10
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Adenylate cyclase inhibition
	Agonist/antagonist binding
	Nociceptin/orphanin FQ
	Opioid receptor
	Site-directed mutagenesis
MeSH keywords:	Adenylate Cyclase -- antagonists & inhibitors
	Animals
	Binding, Competitive
	CHO Cells
	Cell Membrane -- chemistry
	Cricetinae
	Diprenorphine -- pharmacology
	Dynorphins -- metabolism
	Etorphine -- metabolism
	Fentanyl -- analogs & derivatives
	Fentanyl -- metabolism
	Glutamine
	Histamine
	Humans
	Kinetics
	Ligands
	Naltrexone -- analogs & derivatives
	Naltrexone -- metabolism
	Narcotics -- metabolism
	Opioid Peptides -- metabolism
	Opioid Peptides -- pharmacology
	Receptors, Opioid -- agonists
	Receptors, Opioid -- antagonists & inhibitors
	Receptors, Opioid -- chemistry
	Receptors, Opioid -- genetics
	Receptors, Opioid -- metabolism
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0014-5793
	info:doi/10.1016/0014-5793(96)00993-3
	info:pii/0014-5793(96)00993-3
	info:scp/0030583390
	info:pmid/8849681