Titre:
  • Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids.
Auteur:Mollereau, Catherine; Moisand, C; Butour, J L; Parmentier, Marc; Meunier, J C
Informations sur la publication:FEBS letters, 395, 1, page (17-21)
Statut de publication:Publié, 1996-10
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Adenylate cyclase inhibition
Agonist/antagonist binding
Nociceptin/orphanin FQ
Opioid receptor
Site-directed mutagenesis
MeSH keywords:Adenylate Cyclase -- antagonists & inhibitors
Animals
Binding, Competitive
CHO Cells
Cell Membrane -- chemistry
Cricetinae
Diprenorphine -- pharmacology
Dynorphins -- metabolism
Etorphine -- metabolism
Fentanyl -- analogs & derivatives
Fentanyl -- metabolism
Glutamine
Histamine
Humans
Kinetics
Ligands
Naltrexone -- analogs & derivatives
Naltrexone -- metabolism
Narcotics -- metabolism
Opioid Peptides -- metabolism
Opioid Peptides -- pharmacology
Receptors, Opioid -- agonists
Receptors, Opioid -- antagonists & inhibitors
Receptors, Opioid -- chemistry
Receptors, Opioid -- genetics
Receptors, Opioid -- metabolism
Note générale:Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0014-5793
info:doi/10.1016/0014-5793(96)00993-3
info:pii/0014-5793(96)00993-3
info:scp/0030583390
info:pmid/8849681