par Janssen, Thierry ;Petein, Michel ;Van Velthoven, Roland ;Van Leer, Patrick;Fourmarier, Marc;Vanegas Merino, Juan,pablo ;Danguy, André ;Schulman, Claude ;Pasteels, Jacques ;Kiss, Robert
Référence Human pathology, 27, 12, page (1341-1347)
Publication Publié, 1996-12
Référence Human pathology, 27, 12, page (1341-1347)
Publication Publié, 1996-12
Article révisé par les pairs
Résumé : | The histochemical binding pattern of the peanut (Arachis hypogaea) lectin (PNA) was quantitatively described by means of computer-assisted microscope analysis in 28 benign prostatic hyperplasias (BPH), 15 prostatic intraepithelial neoplasias (PIN), and 119 prostatic adenocarcinomas. PNA exhibits nonimmune but selective binding to glycoproteins with beta-D-galactosyl(1,3)-N-acetyl-D-galactosamine residues. We also investigated whether a relationship existed between the number of histochemical-related PNA acceptors and the histochemical prostate-specific antigen (PSA) stain intensity, and between the number of PNA receptors and DNA ploidy level. The results show that neoplastic prostate tissues and high-grade intraepithelial prostatic neoplasias (PIN2_3) exhibit a significantly higher number of PNA acceptors than benign prostatic hyperplasias and low (PIN1) grade prostatic intraepithelial neoplasias. A statistically significant correlation was observed between the number of histochemically related PNA acceptors and PSA immunostain intensity. Lastly, diploid prostatic tumors, whether benign or malignant, exhibited a significantly higher number of PNA acceptors than aneuploid ones. These results suggest that PNA acceptors play an important role in the biology of prostate tumors. |