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Inhibition of gap-junctional intercellular communication between epithelial cells transformed by the activated H-ras-1 oncogene.

par Vanhamme, Luc ;Rolin, Sylvie ;Szpirer, Claude
Référence Experimental cell research, 180, 1, page (297-301)
Publication Publié, 1989-01

Article révisé par les pairs

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Résumé :

In order to study the effects of an activated H-ras-1 oncogene on gap-junctional intercellular communication, we introduced the EJ/T24 H-ras-1 oncogene into cells of the epithelial Clone 9-3 cell line. Gap-junctional intercellular communication was significantly reduced in H-ras-1-transformed Clone 9-3 derivatives; this result shows that transformation by the activated H-ras-1 oncogene can inhibit gap-junctional intercellular communication. We postulate that the activated H-ras-1 oncogene product could mediate this effect through a change in the phosphorylation of the major gap-junction protein.