Titre:
  • Controlled delivery of glial cell line-derived neurotrophic factor by a single tetracycline-inducible AAV vector.
Auteur:Chtarto, Abdelwahed; Yang, Xin; Bockstael, Olivier; Melas, Catherine; Blum, David; Lehtonen, Enni; Abeloos, Laurence; Jaspar, J-M; Levivier, Marc; Brotchi, Jacques; Velu, Thierry; Tenenbaum, Liliane
Informations sur la publication:Experimental neurology, 204, 1, page (387-399)
Statut de publication:Publié, 2007-03
Sujet CREF:Sciences bio-médicales et agricoles
Neurologie
Mots-clés:Adeno-associated virus
Downregulation
Glial cell line-derived neurotrophic factor
Parkinson
Serotype 1
Striatum
Tetracycline-inducible
Tyrosine hydroxylase
MeSH keywords:Animals
Brain -- metabolism
Cell Line, Tumor
Corpus Striatum -- metabolism
DNA, Complementary -- metabolism
Dependovirus -- genetics
Dependovirus -- metabolism
Dose-Response Relationship, Drug
Down-Regulation
Doxycycline -- administration & dosage
Doxycycline -- pharmacology
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression
Gene Transfer Techniques
Genetic Vectors -- drug effects
Glial Cell Line-Derived Neurotrophic Factor -- genetics
Green Fluorescent Proteins -- genetics
Humans
Immunohistochemistry
Injections
Rats
Rats, Sprague-Dawley
Tetracyclines -- pharmacology
Time Factors
Transduction, Genetic
Transgenes
Tyrosine 3-Monooxygenase -- metabolism
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0014-4886
info:doi/10.1016/j.expneurol.2006.11.014
info:pii/S0014-4886(06)00630-3
info:scp/33847261478
info:pmid/17223106