Titre:
  • Reversible neurochemical changes mediated by delayed intrastriatal glial cell line-derived neurotrophic factor gene delivery in a partial Parkinson's disease rat model.
Auteur:Yang, Xin; Mertens, Birgit; Lehtonen, Enni; Vercammen, Linda; Bockstael, Olivier; Chtarto, Abdelwahed; Levivier, Marc; Brotchi, Jacques; Michotte, Yvette; Baekelandt, Veerle; Sarre, Sophie; Tenenbaum, Liliane
Informations sur la publication:The journal of gene medicine, 11, 10, page (899-912)
Statut de publication:Publié, 2009-10
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:6-hydroxydopamine
Adeno-associated viral vector
Glial cell line-derived neurotrophic factor
Parkinson's disease
Phosphorylation
Tetracycline-inducible
Tyrosine hydroxylase
MeSH keywords:Adrenergic Agents -- administration & dosage
Adrenergic Agents -- adverse effects
Animals
Dependovirus -- genetics
Dopamine -- analysis
Dopamine -- biosynthesis
Doxycycline -- administration & dosage
Female
Gene Expression -- drug effects
Gene Transfer Techniques
Genetic Vectors -- administration & dosage
Genetic Vectors -- genetics
Genetic Vectors -- metabolism
Glial Cell Line-Derived Neurotrophic Factor -- administration & dosage
Glial Cell Line-Derived Neurotrophic Factor -- biosynthesis
Glial Cell Line-Derived Neurotrophic Factor -- genetics
Humans
Motor Activity -- drug effects
Oxidopamine -- administration & dosage
Oxidopamine -- adverse effects
Parkinson Disease, Secondary -- chemically induced
Parkinson Disease, Secondary -- metabolism
Parkinson Disease, Secondary -- therapy
Rats
Time Factors
Tyrosine 3-Monooxygenase -- analysis
Tyrosine 3-Monooxygenase -- biosynthesis
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:1099-498X
info:doi/10.1002/jgm.1377
info:scp/72449188768
info:pmid/19639608