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Trypanosoma brucei: a surface antigen mRNA is discontinuously transcribed from two distinct chromosomes

par Guyaux, Michel;Cornelissen, A W;Pays, Etienne ;Steinert, Maurice ;Borst, P
Référence EMBO journal, 4, 4, page (995-998)
Publication Publié, 1985-04

Article révisé par les pairs

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Résumé :

The mRNAs for variant surface glycoproteins (VSGs) and many other proteins in Trypanosoma brucei start with the same sequence of 35 nucleotides, encoded by a separate mini-exon. There are approximately 200 mini-exon genes per trypanosome and these are highly clustered on large chromosomes. We have found two trypanosome variants that express a VSG gene located on a small, 225-kb chromosome. Each gene yields a mRNA containing the 35-nucleotide sequence even though the 225-kb chromosome does not contain a complete mini-exon gene. These results provide a strong support for the hypothesis that transcription of protein-coding genes in trypanosomes is discontinuous.