par Ott, M;Emiliani, Serena;Van Lint, Carine 
;Herbein, Georges;Lovett, J;Chirmule, N;McCloskey, T;Pahwa, S;Verdin, Eric
Référence Science, 275, 5305, page (1481-1485)
Publication Publié, 1997
;Herbein, Georges;Lovett, J;Chirmule, N;McCloskey, T;Pahwa, S;Verdin, Eric Référence Science, 275, 5305, page (1481-1485)
Publication Publié, 1997
Article révisé par les pairs
| Résumé : | Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients. Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors. Expression of the HIV-1 transactivator Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28. IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat. |
