Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice.

Mascia, M S; Obinu, M C; Ledent, Catherine; Parmentier, Marc; Böhme, Georg Andrees; Imperato, Assunta; Fratta, W

doi:doi/10.1016/S0014-2999(99)00656-1

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Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice.

par Mascia, M S ;Obinu, M C ;Ledent, Catherine

;Parmentier, Marc

;Böhme, Georg Andrees ;Imperato, Assunta ;Fratta, W
Référence European journal of pharmacology, 383, 3, page (R1-R2)
Publication Publié, 1999-11

Article révisé par les pairs

Résumé :

Morphine (10 and 20 mg/kg, s.c.) does not modify dopamine release in the nucleus accumbens of cannabinoid CB(1) knock-out mice under conditions where it dose-dependently stimulates the release of dopamine in the corresponding wild-type mice. These results demonstrate that cannabinoid CB(1) receptors, regulate mesolimbic dopaminergic transmission in brain areas known to be involved in the reinforcing effects of morphine.

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