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Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.

par Jhiang, S M;Sagartz, J E;Tong, Q;Parker-Thornburg, J;Capen, C C;Cho, Jung Yeon;Xing, S;Ledent, Catherine
Référence Endocrinology, 137, 1, page (375-378)
Publication Publié, 1996-01

Article révisé par les pairs

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Résumé :

The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.