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A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei.

par García-Salcedo, José A;Gijón, Purificación;Nolan, Derek ;Tebabi, Patricia ;Pays, Etienne
Référence EMBO journal, 22, 21, page (5851-5862)
Publication Publié, 2003-11

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Titre:	A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei.
Auteur:	García-Salcedo, José A; Gijón, Purificación; Nolan, Derek; Tebabi, Patricia; Pays, Etienne
Informations sur la publication:	EMBO journal, 22, 21, page (5851-5862)
Statut de publication:	Publié, 2003-11
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	DNA damage
	Histone deacetylase
	Histone ribosyltransferase
	SIR2 homologue
	Trypanosoma
MeSH keywords:	Alkylating Agents -- toxicity
	Animals
	DNA Damage
	DNA Repair -- genetics
	DNA Repair -- physiology
	Genes, Protozoan
	Histone Deacetylases -- metabolism
	Histones -- metabolism
	Nuclear Proteins -- metabolism
	Protozoan Proteins -- metabolism
	Sirtuins -- metabolism
	Substrate Specificity
	Trypanosoma brucei brucei -- drug effects
	Trypanosoma brucei brucei -- genetics
	Trypanosoma brucei brucei -- metabolism
Note générale:	In Vitro
	Journal Article
	Research Support, Non-U.S. Gov't
	FLWIN
Langue:	Anglais
Identificateurs:	urn:issn:0261-4189
	info:doi/10.1093/emboj/cdg553
	info:scp/0242556798
	info:pmid/14592982
	PMC275410