par Dehaye, Jean-Paul ;Caulier, C.;Delporte, Christine
Référence Archives of oral biology, 36, 5, page (335-340)
Publication Publié, 1991
Article révisé par les pairs
Résumé : The effect of barium on isolated acini was tested. Barium in the 0.1-10mM concentration range non-competitively inhibited the efflux of86Rb+ stimulated by carbamylcholine or substance P. This inhibition was independent of the presence of calcium in the extracellular medium. In the same preparation, barium did not affect the efflux of45Ca2+ but, at a 10 mM concentration, it increased amylase release by 70%. Removal of extracellular calcium decreased basal amylase release and the response to carbamylcholine. Adding back calcium or barium to the incubation medium increased basal and carbamylcholine-stimulated amylase secretion, but calcium was more effective than barium. These results suggest that barium has two opposite effects on calcium-regulated processes in rat parotid gland: (1) it is an inhibitor of calcium-activated potassium channels; (2) it is a partial agonist of calcium-activated amylase secretion. © 1991 Pergamon Press plc.