par Forgeur, A;Svoboda, Michal 
;Winand, Jacques ;Robberecht, Patrick ;Delporte, Christine
Référence Molecular and cellular endocrinology, 150, 1-2, page (189-193)
Publication Publié, 1999-04
;Winand, Jacques ;Robberecht, Patrick ;Delporte, Christine Référence Molecular and cellular endocrinology, 150, 1-2, page (189-193)
Publication Publié, 1999-04
Article révisé par les pairs
| Résumé : | Pituitary adenylyl cyclase activating polypeptide (PACAP-27), forskoline and carbachol increased type A atrial natriuretic peptide receptor (NPR-A) density, as well as NPR-A mRNA level, in the human neuroblastoma NB-OK-1 cell line. TPA did not have any effect per se, but blunted the effect of PACAP-27 on both NPR-A density and NPR-A mRNA. The half-life of the NPR-A mRNA was not modified by any of the agents tested. Our data support an original transcriptional upregulation of human NPR-A in response to cAMP-induced agents, and in response to carbachol. |
