par Lonez, Caroline 
;Vandenbranden, Michel ;Ouali, Mustapha ;Legat, Amandine ;Ruysschaert, Jean Marie ;Elouahabi, Abdelatif
Référence Molecular membrane biology, 23, 3, page (227-234)
Publication Publié, 2006
;Vandenbranden, Michel ;Ouali, Mustapha ;Legat, Amandine ;Ruysschaert, Jean Marie ;Elouahabi, Abdelatif Référence Molecular membrane biology, 23, 3, page (227-234)
Publication Publié, 2006
Article révisé par les pairs
| Résumé : | It has been shown that a preinjection of diC14-amidine cationic liposomes decreased TNF-alpha secretion induced by lipoplexes intravenous injection. We showed here that free cationic liposomes inhibit CpG sequences- or lipopolysaccharides-induced TNF-alpha secretion by macrophages. Surprisingly, this effect was strictly dependent on serum. Free cationic liposomes alone did not reveal any anti-inflammatory activity. Low-density lipoproteins and triglyceride-rich lipoproteins were identified as the serum components that confer to the liposomes an anti-inflammatory activity. Lipid fractions of these lipoproteins were able to reproduce the effect of the total lipoproteins and could inhibit, in association with diC14-amidine liposomes, the CpG-induced TNF-alpha secretion. Serum components confer to cationic liposomes new properties that can be used to modulate the inflammatory response directed against CpG sequences and lipopolysaccharides. |
