par Rabin, M;Barker, P E;Ruddle, F H;Brocas, Huguette;Targovnik, H. M.;Vassart, Gilbert 
Référence Somatic cell and molecular genetics, 11, 4, page (397-402)
Publication Publié, 1985-07
Référence Somatic cell and molecular genetics, 11, 4, page (397-402)
Publication Publié, 1985-07
Article révisé par les pairs
| Résumé : | The human thyroglobulin structural gene (TG) was mapped to the long arm of chromosome 8 by blot hydridization of a TG cDNA probe to DNA from 21 human X mouse somatic cell hybrids containing overlapping subsets of human chromosomes. In situ hybridization of the TG probe to metaphase chromosomes from a karyotypically normal human lymphoblastoid cell line, JS, localized the TG gene to within the region 8q23----q24.3. Thus, the TG and c-myc genes map to the same chromosome band in normal human cells. In a human colon carcinoma cell line (COLO 320 DM) which contains amplified c-myc, the TG gene is not amplified and hence it lies outside the amplification domain. |
