par Lagneaux, Laurence 
;Delforge, Alain ;De Bruyn, Cécile ;Bernier, Michel ;Bron, Dominique
Référence Leukemia & lymphoma, 35, 5-6, page (445-453)
Publication Publié, 1999-11
;Delforge, Alain ;De Bruyn, Cécile ;Bernier, Michel ;Bron, Dominique Référence Leukemia & lymphoma, 35, 5-6, page (445-453)
Publication Publié, 1999-11
Article révisé par les pairs
| Résumé : | B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of monoclonal long-lived B cells which are apparently resistant to normal apoptotic regulation. Since bone marrow stromal cells play an essential role in B lymphopoiesis, we have investigated whether stromal cells influence B-CLL cell survival. Our results indicate that intimate contact with stromal cells reduces B-CLL cell apoptosis and prevents the loss of bcl-2 protein expression. Binding of B-CLL cells to stromal cells requires simultaneous action of beta1 and beta2 integrins. The interaction between B-CLL cells and other cell types seems important for their survival and may represent an important mechanism underlying accumulation of malignant cells in B-CLL patients. |
