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Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.

par Hostens, K;Pavlovic, D;Zambre, Y;Ling, Z;Van Schravendijk, C.;Eizirik, Decio L. ;Pipeleers, Daniel
Référence The Journal of clinical investigation, 104, 1, page (67-72)
Publication Publié, 1999

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Titre:	Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.
Auteur:	Hostens, K; Pavlovic, D; Zambre, Y; Ling, Z; Van Schravendijk, C.; Eizirik, Decio L.; Pipeleers, Daniel
Informations sur la publication:	The Journal of clinical investigation, 104, 1, page (67-72)
Statut de publication:	Publié, 1999
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adolescent
	Adult
	Apoptosis
	Biological Markers
	Cells, Cultured
	Culture Media, Conditioned -- chemistry
	Cytokines -- pharmacology
	Cytokines -- toxicity
	Diabetes Mellitus, Type 1 -- immunology
	Diabetes Mellitus, Type 1 -- prevention & control
	Drug Synergism
	Humans
	Hyperinsulinism -- chemically induced
	Insulin -- secretion
	Interferon-gamma -- pharmacology
	Interferon-gamma -- toxicity
	Interleukin-1 -- pharmacology
	Interleukin-1 -- toxicity
	Islets of Langerhans -- cytology
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- immunology
	Islets of Langerhans -- secretion
	Middle Aged
	Prediabetic State -- diagnosis
	Prediabetic State -- physiopathology
	Pro-Opiomelanocortin -- metabolism
	Proinsulin -- biosynthesis
	Proinsulin -- genetics
	Proinsulin -- secretion
	Proprotein Convertase 2
	Reverse Transcriptase Polymerase Chain Reaction
	Secretory Rate -- drug effects
	Subtilisins -- metabolism
	Tumor Necrosis Factor-alpha -- pharmacology
	Tumor Necrosis Factor-alpha -- toxicity
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0021-9738
	info:doi/10.1172/JCI6438
	info:pmid/10393700
	PMC408405