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Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.

par Eizirik, Decio L. ;Sandler, S;Ahnström, G;Welsh, M
Référence Biochemical pharmacology, 42, 12, page (2275-2282)
Publication Publié, 1991

Article révisé par les pairs

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Titre:	Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Auteur:	Eizirik, Decio L.; Sandler, S; Ahnström, G; Welsh, M
Informations sur la publication:	Biochemical pharmacology, 42, 12, page (2275-2282)
Statut de publication:	Publié, 1991
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Adenine -- analogs & derivatives
	Adenine -- analysis
	Alkylating Agents -- pharmacology
	Animals
	Cytochrome b Group -- genetics
	DNA -- metabolism
	Dose-Response Relationship, Drug
	Glucagon -- genetics
	Glucose -- pharmacology
	Guanine -- analogs & derivatives
	Guanine -- analysis
	Immunoblotting
	Insulin -- analysis
	Insulin -- genetics
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- metabolism
	Islets of Langerhans -- physiology
	Male
	Methyl Methanesulfonate -- pharmacology
	Methylnitrosourea -- pharmacology
	Mice
	Mitochondria -- drug effects
	RNA, Messenger -- analysis
	Streptozocin -- pharmacology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0006-2952
	info:pmid/1837218