TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture.

Del Marmol, Véronique; Ito, S; Jackson, I; Vachtenheim, J; Berr, Pascale; Ghanem, Ghanem Elias; Morandini, R; Wakamatsu, K; Huez, Georges

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TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture.

par Del Marmol, Véronique

;Ito, S ;Jackson, I ;Vachtenheim, J ;Berr, Pascale

;Ghanem, Ghanem Elias

;Morandini, R ;Wakamatsu, K ;Huez, Georges

Référence FEBS letters, 327, 3, page (307-310)
Publication Publié, 1993-08

Article révisé par les pairs

Résumé :

We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.

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