par Brion, Jean Pierre ;Couck, A M;Flament Durand, Jacqueline
Référence Acta Neuropathologica, 64, 2, page (148-152)
Publication Publié, 1984
Référence Acta Neuropathologica, 64, 2, page (148-152)
Publication Publié, 1984
Article révisé par les pairs
Résumé : | Enriched fractions of "tangles" obtained from cases of Alzheimer's disease have been observed by negative staining and platinum: iridium shadowing, and also after treatment with sodium dodecyl sulfate and urea. Abnormal filaments with a 80-nm periodic constriction exhibited a substructure consisting of six protofilaments. They also showed a periodic right-handed twist. Some fibrils with a 160-nm periodic constriction were made up of four protofilaments. These features are discussed in view of known fibrous protein models, especially neurofilaments. |