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Topsentins, new toxic bis-indole alkaloids from the marine sponge Topsentia genitrix

par Bartik, Kristin ;Braekman, Jean Claude ;Daloze, Désiré ;Stoller, Catherine ;Huysecom, Joëlle;Vandevyver, Gysèle;Ottinger, Robert
Référence Canadian journal of chemistry, 65, 9, page (2118-2121)
Publication Publié, 1987

Article révisé par les pairs

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Résumé :

Three new bis-indole alkaloids, topsentin-A (1), -B 1 (2), and -B2 (3) have been isolated from the Mediterranean sponge Topsentia genitrix and their structure determined by spectroscopic methods. These compounds are weakly toxic for fish and for dissociated cells of the freshwater sponge Ephydatiafluviatilis and thus might be partially responsible for the chemical defense of the sponge.