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Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients.

par Bulitta, Jürgen B;Zhao, Ping;Arnold, Robert D;Kessler, Dean R;Daifuku, Richard;Pratt, James;Luciano, Gabriel;Hanauske, Axel-R;Gelderblom, Hans;Awada, Ahmad ;Jusko, William J
Référence Cancer chemotherapy and pharmacology, 63, 6, page (1049-1063)
Publication Publié, 2009-05

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Titre:	Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients.
Auteur:	Bulitta, Jürgen B; Zhao, Ping; Arnold, Robert D; Kessler, Dean R; Daifuku, Richard; Pratt, James; Luciano, Gabriel; Hanauske, Axel-R; Gelderblom, Hans; Awada, Ahmad; Jusko, William J
Informations sur la publication:	Cancer chemotherapy and pharmacology, 63, 6, page (1049-1063)
Statut de publication:	Publié, 2009-05
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Mechanistic modeling
	Non-hematological malignancies
	NONMEM
	Paclitaxel
	Population pharmacokinetics
	Solubility limited disposition model
	Ultrafiltration
MeSH keywords:	Adult
	Antineoplastic Agents, Phytogenic -- administration & dosage
	Antineoplastic Agents, Phytogenic -- blood
	Antineoplastic Agents, Phytogenic -- chemistry
	Antineoplastic Agents, Phytogenic -- pharmacokinetics
	Antineoplastic Agents, Phytogenic -- therapeutic use
	Chemistry, Pharmaceutical
	Chromatography, Liquid
	Cross-Over Studies
	Drug Delivery Systems -- methods
	Female
	Humans
	Leukocyte Count
	Linear Models
	Male
	Middle Aged
	Models, Biological
	Monte Carlo Method
	Nanoparticles
	Neoplasms -- drug therapy
	Paclitaxel -- administration & dosage
	Paclitaxel -- blood
	Paclitaxel -- chemistry
	Paclitaxel -- pharmacokinetics
	Paclitaxel -- therapeutic use
	Structure-Activity Relationship
	Tandem Mass Spectrometry
	Tissue Distribution
Note générale:	Journal Article
	Multicenter Study
	Randomized Controlled Trial
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0344-5704
	info:doi/10.1007/s00280-008-0827-2
	info:scp/63949086668
	info:pmid/18791718