Titre:
  • Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer.
Auteur:Zhang, Steven; Zannikos, Peter; Awada, Ahmad; Piccart-Gebhart, Martine; Dirix, Luc Y; Fumoleau, Pierre; Verhaeghe, Tom; Francois, Marc; De Porre, Peter
Informations sur la publication:Journal of clinical pharmacology, 46, 10, page (1116-1127)
Statut de publication:Publié, 2006-10
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Intravenous infusion
Metabolite
Oral administration
Pharmacokinetics
Protein binding
Tipifarnib
MeSH keywords:Administration, Oral
Adult
Aged
Area Under Curve
Biological Availability
Dose-Response Relationship, Drug
Drug Administration Schedule
Enzyme Inhibitors -- administration & dosage
Enzyme Inhibitors -- pharmacokinetics
Farnesyltranstransferase -- antagonists & inhibitors
Female
Glucuronides -- metabolism
Glycoproteins -- metabolism
Humans
Infusions, Intravenous
Male
Metabolic Clearance Rate
Middle Aged
Neoplasms -- drug therapy
Neoplasms -- metabolism
Protein Binding
Quinolones -- metabolism
Quinolones -- pharmacokinetics
Quinolones -- therapeutic use
Serum Albumin -- metabolism
Tablets
Treatment Outcome
Note générale:Journal Article
Randomized Controlled Trial
FLWIN
Langue:Anglais
Identificateurs:urn:issn:0091-2700
info:doi/10.1177/0091270006291034
info:pii/46/10/1116
info:scp/33748643781
info:pmid/16988200