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Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer.

par Zhang, Steven;Zannikos, Peter;Awada, Ahmad ;Piccart-Gebhart, Martine ;Dirix, Luc Y;Fumoleau, Pierre;Verhaeghe, Tom;Francois, Marc;De Porre, Peter
Référence Journal of clinical pharmacology, 46, 10, page (1116-1127)
Publication Publié, 2006-10

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Titre:	Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer.
Auteur:	Zhang, Steven; Zannikos, Peter; Awada, Ahmad; Piccart-Gebhart, Martine; Dirix, Luc Y; Fumoleau, Pierre; Verhaeghe, Tom; Francois, Marc; De Porre, Peter
Informations sur la publication:	Journal of clinical pharmacology, 46, 10, page (1116-1127)
Statut de publication:	Publié, 2006-10
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Intravenous infusion
	Metabolite
	Oral administration
	Pharmacokinetics
	Protein binding
	Tipifarnib
MeSH keywords:	Administration, Oral
	Adult
	Aged
	Area Under Curve
	Biological Availability
	Dose-Response Relationship, Drug
	Drug Administration Schedule
	Enzyme Inhibitors -- administration & dosage
	Enzyme Inhibitors -- pharmacokinetics
	Farnesyltranstransferase -- antagonists & inhibitors
	Female
	Glucuronides -- metabolism
	Glycoproteins -- metabolism
	Humans
	Infusions, Intravenous
	Male
	Metabolic Clearance Rate
	Middle Aged
	Neoplasms -- drug therapy
	Neoplasms -- metabolism
	Protein Binding
	Quinolones -- metabolism
	Quinolones -- pharmacokinetics
	Quinolones -- therapeutic use
	Serum Albumin -- metabolism
	Tablets
	Treatment Outcome
Note générale:	Journal Article
	Randomized Controlled Trial
	FLWIN
Langue:	Anglais
Identificateurs:	urn:issn:0091-2700
	info:doi/10.1177/0091270006291034
	info:pii/46/10/1116
	info:scp/33748643781
	info:pmid/16988200