par Otrock, Zaher K;Hatoum, Hassan A;Awada, Ahmad 
;Ishak, Rim S;Shamseddine, Ali I
Référence Critical reviews in oncology/hematology, 70, 2, page (93-102)
Publication Publié, 2009-05
;Ishak, Rim S;Shamseddine, Ali IRéférence Critical reviews in oncology/hematology, 70, 2, page (93-102)
Publication Publié, 2009-05
Article révisé par les pairs
| Résumé : | Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy. |
